Environmental Enrichment Reduces Neuronal Intranuclear Inclusion Load But Has No Effect on Messenger RNA Expression in a Mouse Model of Huntington Disease

ABSTRACT Huntington disease (HD) is a fatal neurodegenerative disease with no effective treatment. In the R6/1 mouse model of HD, environmental enrichment delays the neurologic phenotype onset and prevents cere- bral volume loss by unknown molecular mechanisms. We examined the effects of environmental enrichment on well-characterized neuro- pathological parameters in a mouse model of HD.…

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